The Institute for
Scientific Exchange, Inc. Presents:
|
ISE Training Courses in Drug Development: Symposium
Venue: Edgewater Hotel
|
The Institute for
Scientific Exchange, Inc. Presents:
|
ISE Training Courses in Drug Development: Symposium
Venue: Edgewater Hotel
|
Exhibitor:
In Vitro Evaluation
of ADMET Drug Properties
15235 Shady
Course Description: A comprehensive course on the
theory and practice of in vitro
evaluation of drug properties including absorption, metabolism, drug-drug
interactions, and toxicity. The course
is designed for novice practitioners who intend to apply in vitro ADMET assays in drug development and also as a refresher
course for veterans of the field. The
lecture will end with an open discussion on the latest findings. Students are encouraged to bring real life
problems for discussion.
Length of Lecture: ½ day
Course syllabus:
·
Mechanisms
of drug absorption
·
Cell-based
systems for drug absorption
·
Artificial
membrane systems
·
Drug
metabolizing enzymes
·
Metabolic
stability evaluation
·
Metabolite
identification
·
Species
comparison
·
Examples
of drug-drug interactions
·
Enzyme
inhibition
·
Enzyme
induction
·
Transporter-based
drug interactions
·
Examples
of toxic drugs and toxic mechanisms
·
Screening
for acute drug toxicity including general cytotoxicity, hepatotoxicity,
neurotoxicity, and cardiotoxicity
·
Genotoxicity
evaluation
·
Toxicogenomics
Summary of lecture and open discussion
END OF COURSE